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oral eplerenone  (Pfizer Inc)

 
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    Structured Review

    Pfizer Inc oral eplerenone
    Oral Eplerenone, supplied by Pfizer Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/eplerenone/eplerenone/pm41751267-54-16-19
    Average 86 stars, based on 1 article reviews
    oral eplerenone - by Bioz Stars, 2026-09
    86/100 stars

    Images

    Related Articles

    Permeability:

    Article Title: A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers.
    Article Snippet: Eplerenone was provided by Pfizer.

    Article Title: The Role of Aldosterone in Vascular Permeability in Diabetes
    Article Snippet: On day 35, rats were treated with eplerenone (EPL; 100 mg/kg/day; Inspra, Pfizer, New York, NY, USA) in a 5% gum arabic solution or with the vehicle alone (CON), administered by intragastric gavage for 10 days.

    Solvent:

    Article Title: A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers.
    Article Snippet: Eplerenone was provided by Pfizer.

    Article Title: The Role of Aldosterone in Vascular Permeability in Diabetes
    Article Snippet: On day 35, rats were treated with eplerenone (EPL; 100 mg/kg/day; Inspra, Pfizer, New York, NY, USA) in a 5% gum arabic solution or with the vehicle alone (CON), administered by intragastric gavage for 10 days.

    Enzyme-linked Immunosorbent Assay:

    Article Title: A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers.
    Article Snippet: Eplerenone was provided by Pfizer.

    Article Title: The Role of Aldosterone in Vascular Permeability in Diabetes
    Article Snippet: On day 35, rats were treated with eplerenone (EPL; 100 mg/kg/day; Inspra, Pfizer, New York, NY, USA) in a 5% gum arabic solution or with the vehicle alone (CON), administered by intragastric gavage for 10 days.

    Immunohistochemistry:

    Article Title: A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers.
    Article Snippet: Eplerenone was provided by Pfizer.

    Article Title: The Role of Aldosterone in Vascular Permeability in Diabetes
    Article Snippet: On day 35, rats were treated with eplerenone (EPL; 100 mg/kg/day; Inspra, Pfizer, New York, NY, USA) in a 5% gum arabic solution or with the vehicle alone (CON), administered by intragastric gavage for 10 days.

    Quantitative RT-PCR:

    Article Title: A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers.
    Article Snippet: Eplerenone was provided by Pfizer.

    Article Title: The Role of Aldosterone in Vascular Permeability in Diabetes
    Article Snippet: On day 35, rats were treated with eplerenone (EPL; 100 mg/kg/day; Inspra, Pfizer, New York, NY, USA) in a 5% gum arabic solution or with the vehicle alone (CON), administered by intragastric gavage for 10 days.

    Real-time Polymerase Chain Reaction:

    Article Title: A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers.
    Article Snippet: Eplerenone was provided by Pfizer.

    Article Title: The Role of Aldosterone in Vascular Permeability in Diabetes
    Article Snippet: On day 35, rats were treated with eplerenone (EPL; 100 mg/kg/day; Inspra, Pfizer, New York, NY, USA) in a 5% gum arabic solution or with the vehicle alone (CON), administered by intragastric gavage for 10 days.

    Staining:

    Article Title: A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers.
    Article Snippet: Eplerenone was provided by Pfizer.

    Article Title: The Role of Aldosterone in Vascular Permeability in Diabetes
    Article Snippet: On day 35, rats were treated with eplerenone (EPL; 100 mg/kg/day; Inspra, Pfizer, New York, NY, USA) in a 5% gum arabic solution or with the vehicle alone (CON), administered by intragastric gavage for 10 days.

    Concentration Assay:

    Article Title: A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers.
    Article Snippet: Eplerenone was provided by Pfizer.

    Article Title: The Role of Aldosterone in Vascular Permeability in Diabetes
    Article Snippet: On day 35, rats were treated with eplerenone (EPL; 100 mg/kg/day; Inspra, Pfizer, New York, NY, USA) in a 5% gum arabic solution or with the vehicle alone (CON), administered by intragastric gavage for 10 days.

    Immunohistochemical staining:

    Article Title: A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers.
    Article Snippet: Eplerenone was provided by Pfizer.

    Article Title: The Role of Aldosterone in Vascular Permeability in Diabetes
    Article Snippet: On day 35, rats were treated with eplerenone (EPL; 100 mg/kg/day; Inspra, Pfizer, New York, NY, USA) in a 5% gum arabic solution or with the vehicle alone (CON), administered by intragastric gavage for 10 days.

    Expressing:

    Article Title: A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers.
    Article Snippet: Eplerenone was provided by Pfizer.

    Article Title: The Role of Aldosterone in Vascular Permeability in Diabetes
    Article Snippet: On day 35, rats were treated with eplerenone (EPL; 100 mg/kg/day; Inspra, Pfizer, New York, NY, USA) in a 5% gum arabic solution or with the vehicle alone (CON), administered by intragastric gavage for 10 days.

    Activation Assay:

    Article Title: A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers.
    Article Snippet: Eplerenone was provided by Pfizer.

    Article Title: The Role of Aldosterone in Vascular Permeability in Diabetes
    Article Snippet: On day 35, rats were treated with eplerenone (EPL; 100 mg/kg/day; Inspra, Pfizer, New York, NY, USA) in a 5% gum arabic solution or with the vehicle alone (CON), administered by intragastric gavage for 10 days.

    Protein-Protein interactions:

    Article Title: A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers.
    Article Snippet: Eplerenone was provided by Pfizer.

    Article Title: The Role of Aldosterone in Vascular Permeability in Diabetes
    Article Snippet: On day 35, rats were treated with eplerenone (EPL; 100 mg/kg/day; Inspra, Pfizer, New York, NY, USA) in a 5% gum arabic solution or with the vehicle alone (CON), administered by intragastric gavage for 10 days.

    Control:

    Article Title: A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers.
    Article Snippet: Eplerenone was provided by Pfizer.

    Article Title: The Role of Aldosterone in Vascular Permeability in Diabetes
    Article Snippet: On day 35, rats were treated with eplerenone (EPL; 100 mg/kg/day; Inspra, Pfizer, New York, NY, USA) in a 5% gum arabic solution or with the vehicle alone (CON), administered by intragastric gavage for 10 days.

    Clinical Proteomics:

    Article Title: A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers.
    Article Snippet: Eplerenone was provided by Pfizer.

    Article Title: The Role of Aldosterone in Vascular Permeability in Diabetes
    Article Snippet: On day 35, rats were treated with eplerenone (EPL; 100 mg/kg/day; Inspra, Pfizer, New York, NY, USA) in a 5% gum arabic solution or with the vehicle alone (CON), administered by intragastric gavage for 10 days.

    Activity Assay:

    Article Title: A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers.
    Article Snippet: Eplerenone was provided by Pfizer.

    Article Title: The Role of Aldosterone in Vascular Permeability in Diabetes
    Article Snippet: On day 35, rats were treated with eplerenone (EPL; 100 mg/kg/day; Inspra, Pfizer, New York, NY, USA) in a 5% gum arabic solution or with the vehicle alone (CON), administered by intragastric gavage for 10 days.

    Zymography:

    Article Title: A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers.
    Article Snippet: Eplerenone was provided by Pfizer.

    Article Title: The Role of Aldosterone in Vascular Permeability in Diabetes
    Article Snippet: On day 35, rats were treated with eplerenone (EPL; 100 mg/kg/day; Inspra, Pfizer, New York, NY, USA) in a 5% gum arabic solution or with the vehicle alone (CON), administered by intragastric gavage for 10 days.

    Molecular Weight:

    Article Title: A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers.
    Article Snippet: Eplerenone was provided by Pfizer.

    Article Title: The Role of Aldosterone in Vascular Permeability in Diabetes
    Article Snippet: On day 35, rats were treated with eplerenone (EPL; 100 mg/kg/day; Inspra, Pfizer, New York, NY, USA) in a 5% gum arabic solution or with the vehicle alone (CON), administered by intragastric gavage for 10 days.

    Marker:

    Article Title: A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers.
    Article Snippet: Eplerenone was provided by Pfizer.

    Article Title: The Role of Aldosterone in Vascular Permeability in Diabetes
    Article Snippet: On day 35, rats were treated with eplerenone (EPL; 100 mg/kg/day; Inspra, Pfizer, New York, NY, USA) in a 5% gum arabic solution or with the vehicle alone (CON), administered by intragastric gavage for 10 days.

    Lysis:

    Article Title: A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers.
    Article Snippet: Eplerenone was provided by Pfizer.

    Article Title: The Role of Aldosterone in Vascular Permeability in Diabetes
    Article Snippet: On day 35, rats were treated with eplerenone (EPL; 100 mg/kg/day; Inspra, Pfizer, New York, NY, USA) in a 5% gum arabic solution or with the vehicle alone (CON), administered by intragastric gavage for 10 days.

    Western Blot:

    Article Title: A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers.
    Article Snippet: Eplerenone was provided by Pfizer.

    Article Title: The Role of Aldosterone in Vascular Permeability in Diabetes
    Article Snippet: On day 35, rats were treated with eplerenone (EPL; 100 mg/kg/day; Inspra, Pfizer, New York, NY, USA) in a 5% gum arabic solution or with the vehicle alone (CON), administered by intragastric gavage for 10 days.

    Imaging:

    Article Title: A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers.
    Article Snippet: Eplerenone was provided by Pfizer.

    Article Title: The Role of Aldosterone in Vascular Permeability in Diabetes
    Article Snippet: On day 35, rats were treated with eplerenone (EPL; 100 mg/kg/day; Inspra, Pfizer, New York, NY, USA) in a 5% gum arabic solution or with the vehicle alone (CON), administered by intragastric gavage for 10 days.

    Immunofluorescence:

    Article Title: A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers.
    Article Snippet: Eplerenone was provided by Pfizer.

    Article Title: The Role of Aldosterone in Vascular Permeability in Diabetes
    Article Snippet: On day 35, rats were treated with eplerenone (EPL; 100 mg/kg/day; Inspra, Pfizer, New York, NY, USA) in a 5% gum arabic solution or with the vehicle alone (CON), administered by intragastric gavage for 10 days.



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    A The line graph depicts mean activity in light and dark phases of the light/dark response assay. Activity of larvae (96 hpf) is expressed as the distance moved (mm) during each 30-sec recording bin. The total recording period was 30 min with alternating light periods of 7.5 min each (also indicated by light and dark horizontal bars above the x-axis). B The total distance moved in the two light periods in vehicle control and cortisol (5 µg/ml) treated larvae. Representative heat maps of the localization of individual larvae in this phase are shown below the respective bar. C The total distance moved in the two dark periods in vehicle control and cortisol (5 µg/ml) treated larvae. Representative heat maps of the localization of individual larvae in this phase are shown below the respective bar. D The total distance moved by zebrafish larvae (96 hpf) in the light phase after exposure to increasing concentrations of cortisol (10 -10,000 ng/ml; 20 h). E The total distance moved in the light phase of zebrafish larvae (96 hpf) exposed to either a vehicle (0.05% ethanol) or cortisol (5 µg/ml) treatment for 20 h, and exposed to a GR receptor antagonist (Mifepristone; 1.25 µM; 20 h) or an MR antagonist <t>(Eplerenone</t> 1.25 µM; 20 h). F The total distance moved of wildtype (WT) and mutant knockout zebrafish GRKO (nr3c1 ia30 ) and MRKO (nr3c2 inr 11 ) larvae (96 hpf), treated with vehicle (0.05% ethanol) or cortisol (5 µg/ml, 20 h). Bars show mean ± SEM, where each dot represents a single larva (A-D). Data were analyzed using a one-way ANOVA (A) or a two-way ANOVA (B-F; Holm-Sidak post hoc test; p < 0.05) * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p ≤ 0.0001.
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    Image Search Results


    A The line graph depicts mean activity in light and dark phases of the light/dark response assay. Activity of larvae (96 hpf) is expressed as the distance moved (mm) during each 30-sec recording bin. The total recording period was 30 min with alternating light periods of 7.5 min each (also indicated by light and dark horizontal bars above the x-axis). B The total distance moved in the two light periods in vehicle control and cortisol (5 µg/ml) treated larvae. Representative heat maps of the localization of individual larvae in this phase are shown below the respective bar. C The total distance moved in the two dark periods in vehicle control and cortisol (5 µg/ml) treated larvae. Representative heat maps of the localization of individual larvae in this phase are shown below the respective bar. D The total distance moved by zebrafish larvae (96 hpf) in the light phase after exposure to increasing concentrations of cortisol (10 -10,000 ng/ml; 20 h). E The total distance moved in the light phase of zebrafish larvae (96 hpf) exposed to either a vehicle (0.05% ethanol) or cortisol (5 µg/ml) treatment for 20 h, and exposed to a GR receptor antagonist (Mifepristone; 1.25 µM; 20 h) or an MR antagonist (Eplerenone 1.25 µM; 20 h). F The total distance moved of wildtype (WT) and mutant knockout zebrafish GRKO (nr3c1 ia30 ) and MRKO (nr3c2 inr 11 ) larvae (96 hpf), treated with vehicle (0.05% ethanol) or cortisol (5 µg/ml, 20 h). Bars show mean ± SEM, where each dot represents a single larva (A-D). Data were analyzed using a one-way ANOVA (A) or a two-way ANOVA (B-F; Holm-Sidak post hoc test; p < 0.05) * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p ≤ 0.0001.

    Journal: Molecular Psychiatry

    Article Title: Mineralocorticoid and glucocorticoid receptor heterodimers mediate cortisol-induced behavioural changes via modulation of glutamatergic signalling

    doi: 10.1038/s41380-025-03389-z

    Figure Lengend Snippet: A The line graph depicts mean activity in light and dark phases of the light/dark response assay. Activity of larvae (96 hpf) is expressed as the distance moved (mm) during each 30-sec recording bin. The total recording period was 30 min with alternating light periods of 7.5 min each (also indicated by light and dark horizontal bars above the x-axis). B The total distance moved in the two light periods in vehicle control and cortisol (5 µg/ml) treated larvae. Representative heat maps of the localization of individual larvae in this phase are shown below the respective bar. C The total distance moved in the two dark periods in vehicle control and cortisol (5 µg/ml) treated larvae. Representative heat maps of the localization of individual larvae in this phase are shown below the respective bar. D The total distance moved by zebrafish larvae (96 hpf) in the light phase after exposure to increasing concentrations of cortisol (10 -10,000 ng/ml; 20 h). E The total distance moved in the light phase of zebrafish larvae (96 hpf) exposed to either a vehicle (0.05% ethanol) or cortisol (5 µg/ml) treatment for 20 h, and exposed to a GR receptor antagonist (Mifepristone; 1.25 µM; 20 h) or an MR antagonist (Eplerenone 1.25 µM; 20 h). F The total distance moved of wildtype (WT) and mutant knockout zebrafish GRKO (nr3c1 ia30 ) and MRKO (nr3c2 inr 11 ) larvae (96 hpf), treated with vehicle (0.05% ethanol) or cortisol (5 µg/ml, 20 h). Bars show mean ± SEM, where each dot represents a single larva (A-D). Data were analyzed using a one-way ANOVA (A) or a two-way ANOVA (B-F; Holm-Sidak post hoc test; p < 0.05) * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p ≤ 0.0001.

    Article Snippet: Eplerenone , MR antagonist , 1.25 μM [20 h] , Merck Life Sciences.

    Techniques: Activity Assay, Control, Mutagenesis, Knock-Out